Fulcrum Therapeutics, Inc.
Fulcrum Therapeutics, Inc. (FULC) is listed on NASDAQ and classified in Biotechnology, part of the Healthcare sector. It is headquartered in Cambridge, United States and has 9 employees. The company is worth $281.09M. Revenue was $0 in fiscal 2025, down 100.0% from the year before. It reported a net loss of $74.88M. The share price is 76.6% below its 52-week high of $15.74. 6 of the 38 superinvestors we track held it at the end of Q2 2026. The largest position belongs to Ken Griffin (Citadel Advisors), at $9.9M. In that quarter, 5 of them opened or added to the position and 1 reduced it. No open-market insider trades in it were filed over the last 30 days.
Written from the data on this page: SEC filings (13F, Form 4, annual reports) and market prices.
Year by year, from the annual reports; dividends from the payments themselves.
Bars are year-end balances; lines are what happened during the year.
Major managers that reported this stock in their latest 13F.
▼ -74.8% over 5Y.
today you would have $164.86▼ -83.5%
Dividends reinvested, splits accounted for. Past prices say what happened, not what will.
The last 7 closed years, each at that year’s closing price and reported numbers.
| Indicator | Median | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 |
|---|---|---|---|---|---|---|---|---|
| Year-end price | $11.31 | $4.70 | $6.75 | $7.28 | $17.69 | $11.71 | $16.64 | |
| P/S | 43.4x | — | 3.2x | 149.0x | 70.9x | 37.5x | 43.4x | — |
| P/B | 2.3x | 2.2x | 1.0x | 1.8x | 2.3x | 3.4x | 4.0x | 4.5x |
| EPS |
Companies of similar size in Healthcare, for comparison. The columns are the same ones above, in the same order.
| Stock | Price | P/E | P/B | Dividend yield | ROE | Market cap |
|---|---|---|---|---|---|---|
| ANIKAnika Therapeutics, Inc. | $21.09 | — | 2.1x | 0.00% | -2.19% | $282.25M |
| BNTCBenitec Biopharma Inc. | $8.11 | — | 1.6x | 0.00% | -33.21% | $282.9M |
| TMCITreace Medical Concepts Inc | $4.28 | — | 4.1x | 0.00% | -71.99% | $278.35M |
| CLPTClearPoint Neuro, Inc. | $9.07 |
| -$1.18 |
| -$0.16 |
| -$1.59 |
| -$2.44 |
| -$2.29 |
| -$2.79 |
| -$8.13 |
| Profit margin | -802.66% | — | -12.16% | -3470.05% | -1732.43% | -421.89% | -802.66% | — |
| ROE | -41.39% | -21.46% | -4.00% | -41.39% | -55.23% | -38.22% | -74.40% | -94.86% |
Median of the years shown; P/E years above 200x are left out.
| — |
| 25.7x |
| 0.00% |
| -226.52% |
| $276.67M |
| ARTVArtiva Biotherapeutics, Inc. | $5.85 | — | 0.8x | 0.00% | -36.58% | $286.01M |
| SRZNSurrozen, Inc. | $23.44 | — | — | 0.00% | — | $275.5M |