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SEPN
Septerna, Inc.
NASDAQ· Healthcare· Biotechnology· CUSIP 81734D104
$36.35-2.94%Price as of Oct 17, 12:04 UTC · updated once a day, after the close
At a glance
Septerna, Inc. (SEPN) is listed on NASDAQ and classified in Biotechnology, part of the Healthcare sector. It is headquartered in South San Francisco, United States and has 123 employees. The company is worth $1.7B. Revenue was $45.95M in fiscal 2025, up 4174.5% from the year before. It reported a net loss of $48.88M. The share price is 28.9% below its 52-week high of $51.10. 5 of the 38 superinvestors we track held it at the end of Q2 2026. The largest position belongs to Two Sigma (Two Sigma Investments), at $7.4M. In that quarter, 1 of them opened or added to the position and 1 reduced it. Over the last 30 days, company insiders sold $149.64K of its stock on the open market and bought none. All of those sales were scheduled in advance under 10b5-1 plans.
Written from the data on this page: SEC filings (13F, Form 4, annual reports) and market prices.
Key metrics
- Market cap
- $1.7B
- P/E
- —
- Forward P/E
- —
- P/B
- 4.3x
- Dividend yield
- 0.00%
- Payout
- —
- EPS
- -$0.54
- ROE
- -6.34%
- Profit margin
- -24.51%
- Revenue growth
- +22375.60%
- Beta
- —
- 52-week high
- $51.10
- 52-week low
- $17.55
History
Year by year, from the annual reports; dividends from the payments themselves.
Bars are year-end balances; lines are what happened during the year.
Investors holding this
Major managers that reported this stock in their latest 13F.
- Two SigmaAddedTwo Sigma Investments · Q2 2026$7.4M220.89K shares · 0.0% of portfolio
- Israel EnglanderReducedMillennium Management · Q2 2026$1.69M50.56K shares · 0.0% of portfolio
- Renaissance TechnologiesHeldRenaissance Technologies · Q2 2026$1.39M41.42K shares · 0.0% of portfolio
- Cliff AsnessHeldAQR Capital Management · Q2 2026$515.65K15.4K shares · 0.0% of portfolio
Ken GriffinHeldCitadel Advisors · Q2 2026$212.66K6.35K shares · 0.0% of portfolio
Price over time
▲ +58.9% over 5Y.
This stock has less than 5 years of price history — the answer would measure a shorter period than the one asked for.
Dividends reinvested, splits accounted for. Past prices say what happened, not what will.
Indicators, year by year
The last 2 closed years, each at that year’s closing price and reported numbers.
| Indicator | Median | 2025 | 2024 |
|---|---|---|---|
| Year-end price | $27.88 | $22.90 | |
| P/S | — | 27.2x | 946.7x |
| P/B | — | 3.3x | 2.4x |
| EPS | -$1.10 | -$7.26 | |
| Profit margin | — | -106.37% | -6678.88% |
| ROE | — | -12.80% | -17.09% |
Median of the years shown; P/E years above 200x are left out.
Fair price, seven ways
Seven formulas applied to the reported numbers, each with its assumption next to the result. None of them predicts a price.
Earnings
—
This formula has no meaning here — usually a loss, negative cash flow, or a missing input.
Earnings
—
This formula has no meaning here — usually a loss, negative cash flow, or a missing input.
Earnings
—
This formula has no meaning here — usually a loss, negative cash flow, or a missing input.
Earnings
—
This formula has no meaning here — usually a loss, negative cash flow, or a missing input.
Cash flow
$42.73
Cash flow growing 5.0% a year for 10 years, discounted at 10%, then 2.5% forever.
Operating
—
This formula has no meaning here — usually a loss, negative cash flow, or a missing input.
Dividends
—
This formula has no meaning here — usually a loss, negative cash flow, or a missing input.
How the average is calculated
The average of the method families that answered, not of the seven numbers: four of the seven start from the same earnings per share.
Cash flow $42.73÷ 1 =$42.73
$42.73
1 methods answered, across 1 families.
$32.05
Room for errors in the reported numbers.
$36.35
+17.5% from the average.
Models, not forecasts, and not investment advice. How each formula works →
Others in the same sector
Companies of similar size in Healthcare, for comparison. The columns are the same ones above, in the same order.
| Stock | Price | P/E | P/B | Dividend yield | ROE | Market cap |
|---|---|---|---|---|---|---|
| SNDASonida Senior Living Inc | $35.29 | — | 1.9x | 0.00% | -25.24% | $1.7B |
| ANIPAni Pharmaceuticals Inc | $73.75 | 16.0x | 2.6x | 0.00% | 20.46% | $1.69B |
| HCSGHealthcare Services Group Inc | $24.79 | 16.8x | 3.2x | 0.00% | 24.69% | $1.7B |
| SDGRSchrodinger, Inc. | $22.60 | — | 5.0x | 0.00% | -16.18% | $1.69B |
| PSNLPersonalis, Inc. | $15.82 | — | 7.2x | 0.00% | -50.32% | $1.69B |
| OMCLOmnicell Inc | $37.10 | 43.1x | 1.3x | 0.00% | 3.06% | $1.69B |
About the company
- 123
- South San Francisco, United States