Senti Biosciences Holdings, Inc.
How the company evolved, year by year. Revenue and debt come from the annual reports — for most companies, the 10-K filings with the SEC since 2009; dividends from the payments themselves.
The bars are a balance on the closing date; the lines are what happened during the year. Revenue above equity is ordinary, not an anomaly — it means the company turns its capital over more than once a year.
Major managers that reported this stock in their latest 13F.
▼ -99.7% over 5Y.
today you would have $3.31▼ -99.7%
Dividends reinvested, splits accounted for. Past prices say what happened, not what will.
The last 5 closed years. Each multiple uses that year’s closing price and that year’s reported numbers — not today’s. The range is set by the annual reports on record.
| Indicator | Median | 2025 | 2024 | 2023 | 2022 | 2021 |
|---|---|---|---|---|---|---|
| Year-end price | $1.04 | $3.51 | $6.60 | $14.10 | $98.60 | |
| P/S | 13.8x | 1472.3x | 13.8x | 11.8x | 14.5x | 10.6x |
| P/B | 2.0x | 5.8x | 3.6x | 0.5x | 0.5x | — |
| EPS | -$2.73 | -$12.03 | -$16.01 | -$22.30 | -$190.00 |
Companies of similar size in Healthcare, for comparison. The columns are the same ones above, in the same order.
| Stock | Price | P/E | P/B | Dividend yield | ROE | Market cap |
|---|---|---|---|---|---|---|
| PDSBPDS Biotechnology Corp | $0.21 | — | — | — | -543.97% | $11.8M |
| KPRXKiora Pharmaceuticals Inc | $2.62 | — | 0.8x | — | -56.37% | $11.59M |
| ASBPAspire Biopharma Holdings, Inc. | $8.51 | — | 0.9x | — | -1032.14% | $11.94M |
| BLRXBioLineRx Ltd. | $2.60 |
Senti Biosciences Holdings, Inc., a clinical stage biotechnology company, develops cell and gene therapies engineered with its gene circuit platform technologies for patients living with incurable diseases. The company's lead product candidates utilize off-the-shelf healthy adult donor derived natural killer (NK) cells to create CAR-NK cells outfitted with gene circuit technologies in various oncology indications with unmet need. It offers SENTI-202, a logic gated off-the-shelf CAR-NK cell therapy for the treatment of blood cancers and relapsed/refractory hematological malignancies, including acute myeloid leukemia. In addition, the company develops the tumor-associated antigen and protective antigen paired discovery platform to select and validate NOT GATE antigen candidates and identify tumor-associated antigens in cancer cells. Further, its pipeline includes preclinical programs, which comprise a solid tumor cell therapy program; and partnered programs related to cell therapies for regenerative medicines. The company has a strategic collaboration with Celest Therapeutics (Shanghai) Co. Ltd. The company was formerly known as Senti Biosciences, Inc. and changed its name to Senti Biosciences Holdings, Inc. in April 2026. The company was incorporated in 2016 and is headquartered in South San Francisco, California.
Company description provided by Yahoo Finance.
| Profit margin | -2003.59% | -279263.64% | -798.88% | -2774.62% | -1358.14% | -2003.59% |
| ROE | -156.01% | -1099.27% | -205.82% | -106.19% | -45.74% | — |
Median, not average: a single year of near-zero profit produces a P/E of 400 and would drag an average on its own. P/E years above 200x are left out, the same cut the fair price uses — so this median matches the “its own history” method below. Price and EPS have no median: they are series that grow.
| — |
| 0.7x |
| — |
| -46.72% |
| $11.36M |
| ADGMAdagio Medical Holdings, Inc. | $0.51 | — | — | — | -657.76% | $11.35M |
| TOVXTheriva Biologics, Inc. | $0.25 | 0.2x | 0.9x | — | -101.87% | $11.25M |