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Spero Therapeutics, Inc.
Spero Therapeutics, Inc. (SPRO) is listed on NASDAQ and classified in Biotechnology, part of the Healthcare sector. It is headquartered in Cambridge, United States and has 25 employees. The company is worth $64.06M and trades at 7.9x its earnings of the last twelve months; the median for its sector is 24.3x. Revenue was $66.8M in fiscal 2025, up 39.2% from the year before. Net income was $8.57M. The share price is 64.3% below its 52-week high of $3.08. 4 of the 38 superinvestors we track held it at the end of Q2 2026. The largest position belongs to Renaissance Technologies, at $2.09M. In that quarter, 1 of them reduced the position. No open-market insider trades in it were filed over the last 30 days.
Written from the data on this page: SEC filings (13F, Form 4, annual reports) and market prices.
Year by year, from the annual reports; dividends from the payments themselves.
Bars are year-end balances; lines are what happened during the year.
Major managers that reported this stock in their latest 13F.
▼ -92.3% over 5Y.
today you would have $62.64▼ -93.7%
Dividends reinvested, splits accounted for. Past prices say what happened, not what will.
The last 9 closed years, each at that year’s closing price and reported numbers.
| Indicator | Median | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| Year-end price | $2.33 | $1.03 | $1.47 | $1.73 | $16.01 | $19.39 | $9.61 | $6.15 | $11.75 | |
| P/E | — | 15.5x | — | 3.4x | — | — | — | — | — | — |
| P/S | 10.8x | 2.0x | 1.2x | 0.8x |
Seven formulas applied to the reported numbers, each with its assumption next to the result. None of them predicts a price.
Square root of 22.5 × earnings × book value. Blind to intangibles, so it undervalues software and brands.
This formula has no meaning here — usually a loss, negative cash flow, or a missing input.
Median P/E of 24.3 among peers in the sector.
This formula has no meaning here — usually a loss, negative cash flow, or a missing input.
This formula has no meaning here — usually a loss, negative cash flow, or a missing input.
Sector median of 14.1x operating profit, less net debt. Banks have no EBITDA.
Companies of similar size in Healthcare, for comparison. The columns are the same ones above, in the same order.
| Stock | Price | P/E | P/B | Dividend yield | ROE | Market cap |
|---|---|---|---|---|---|---|
| MBOTMicrobot Medical Inc. | $0.95 | — | 0.9x | 0.00% | -32.91% | $63.81M |
| XBITXBiotech Inc. | $2.12 | — | 0.5x | 0.00% | -29.94% | $64.63M |
| CINGCingulate Inc. | $4.36 | — | 2.6x | 0.00% | -198.74% | $63.4M |
| ONCYOncolytics Biotech Inc | $0.50 |
| 1.7x |
| 28.7x |
| 61.3x |
| 10.8x |
| 26.7x |
| 85.3x |
| P/B | 2.0x | 2.3x | 1.2x | 0.7x | 1.2x | 5.9x | 4.3x | 2.6x | 0.9x | 2.0x |
| EPS | $0.15 | -$1.27 | $0.43 | -$1.23 | -$2.91 | -$3.52 | -$3.35 | -$2.60 | -$17.82 |
| Profit margin | -335.59% | 12.83% | -142.91% | 21.98% | -86.74% | -491.89% | -839.23% | -335.59% | -1051.44% | -1957.71% |
| ROE | -59.30% | 14.52% | -148.66% | 21.34% | -61.13% | -101.71% | -59.30% | -81.66% | -36.10% | -45.79% |
Median of the years shown; P/E years above 200x are left out.
This formula has no meaning here — usually a loss, negative cash flow, or a missing input.
The average of the method families that answered, not of the seven numbers: four of the seven start from the same earnings per share.
3 methods answered, across 2 families.
Room for errors in the reported numbers.
+113.8% from the average.
Models, not forecasts, and not investment advice. How each formula works →
| — |
| — |
| 0.00% |
| — |
| $65.31M |
| BMEABiomea Fusion, Inc. | $0.87 | — | 5.2x | 0.00% | -164.14% | $62.82M |
| CSBRChampions Oncology Inc | $4.70 | — | 16.8x | 0.00% | -28.38% | $65.42M |