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IONS
Ionis Pharmaceuticals Inc
NASDAQ· Healthcare· Biotechnology· CUSIP 462222100
$43.91-0.81%Price as of Oct 23, 00:43 UTC · updated once a day, after the close
At a glance
Ionis Pharmaceuticals Inc (IONS) is listed on NASDAQ and classified in Biotechnology, part of the Healthcare sector. It is headquartered in Carlsbad, United States and has 1,480 employees. The company is worth $7.3B. Revenue was $943.71M in fiscal 2025, up 33.8% from the year before. It reported a net loss of $381.39M. The share price is 49.4% below its 52-week high of $86.74. 5 of the 38 superinvestors we track held it at the end of Q2 2026. The largest position belongs to Two Sigma (Two Sigma Investments), at $495.75M. In that quarter, 2 of them opened or added to the position and 2 reduced it. Over the last 30 days, company insiders sold $61.39K of its stock on the open market and bought none.
Written from the data on this page: SEC filings (13F, Form 4, annual reports) and market prices.
Key metrics
- Market cap
- $7.3B
- P/E
- —
- Forward P/E
- —
- P/B
- 16.5x
- Dividend yield
- 0.00%
- Payout
- —
- EPS
- -$3.48
- ROE
- -105.50%
- Profit margin
- -64.66%
- Revenue growth
- -40.70%
- Beta
- 0.38
- 52-week high
- $86.74
- 52-week low
- $42.08
History
Year by year, from the annual reports; dividends from the payments themselves.
Bars are year-end balances; lines are what happened during the year.
Investors holding this
Major managers that reported this stock in their latest 13F.
- Two SigmaAddedTwo Sigma Investments · Q2 2026$495.75M6.25M shares · 0.4% of portfolio
- Renaissance TechnologiesAddedRenaissance Technologies · Q2 2026$44.36M559.41K shares · 0.1% of portfolio
- Israel EnglanderReducedMillennium Management · Q2 2026$22.9M288.87K shares · 0.0% of portfolio
Ken GriffinReducedCitadel Advisors · Q2 2026$18.73M236.28K shares · 0.0% of portfolio- Cliff AsnessHeldAQR Capital Management · Q2 2026$1.75M22.06K shares · 0.0% of portfolio
Price over time
▲ +62.0% over 5Y.
today you would have $1,347.35▲ +34.7%
Dividends reinvested, splits accounted for. Past prices say what happened, not what will.
Indicators, year by year
The last 18 closed years, each at that year’s closing price and reported numbers.
| Indicator | Median | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Year-end price | $79.11 | $34.96 | $50.59 | $37.77 | $30.43 | $56.54 | $60.41 | $54.06 | $50.30 | $47.83 | $61.93 | $61.74 | $39.84 | $10.44 | $7.21 | $10.12 | $11.11 | $14.18 | |
| P/E | 26.1x | — | — | — | — | — | — | 31.8x | 26.1x | 335.3x | — | — | — | — | — | — | — | 7.0x | — |
| P/S | 10.7x | 13.8x | 7.9x | 9.4x | 9.2x | 5.3x | 10.9x | 7.5x | 12.5x | 12.3x | 15.9x | 26.3x | 34.3x | 31.7x | 10.4x | 7.3x | 9.3x | 9.0x | 12.5x |
| P/B | 9.4x | 26.7x | 9.4x | 19.1x | 9.4x | 5.6x | 10.7x | 5.7x | 7.1x | 22.4x | 59.4x | 37.2x | 28.5x | 12.3x | 5.8x | 4.2x | 4.1x | 3.8x | 9.1x |
| EPS | -$2.38 | -$3.04 | -$2.56 | -$1.90 | -$0.20 | -$3.18 | $1.90 | $2.07 | $0.15 | -$0.50 | -$0.74 | -$0.33 | -$0.55 | -$0.65 | -$0.85 | -$0.62 | $1.58 | -$0.19 | |
| Profit margin | -35.76% | -40.41% | -64.37% | -46.50% | -45.92% | -3.53% | -60.92% | 24.78% | 45.65% | 0.07% | -16.20% | -31.12% | -18.20% | -41.17% | -64.16% | -85.58% | -56.47% | 127.52% | -16.95% |
| ROE | -30.44% | -77.98% | -77.15% | -94.72% | -47.08% | -3.71% | -59.77% | 18.91% | 26.12% | 0.12% | -60.66% | -43.97% | -15.12% | -16.03% | -35.83% | -49.47% | -25.05% | 53.16% | -12.33% |
Median of the years shown; P/E years above 200x are left out.
Others in the same sector
Companies of similar size in Healthcare, for comparison. The columns are the same ones above, in the same order.
| Stock | Price | P/E | P/B | Dividend yield | ROE | Market cap |
|---|---|---|---|---|---|---|
| PRAXPraxis Precision Medicines, Inc. | $258.92 | — | 5.4x | 0.00% | -38.86% | $7.23B |
| ALKSAlkermes plc. | $44.18 | 113.3x | 4.1x | 0.00% | 3.85% | $7.41B |
| AMRXAmneal Pharmaceuticals, Inc. | $20.48 | 41.0x | 198.8x | 0.00% | 613.02% | $7.13B |
| SYRESpyre Therapeutics, Inc. | $79.90 | — | 7.4x | 0.00% | -22.98% | $7.47B |
| PACSPACS Group, Inc. | $47.50 | 27.3x | 6.8x | 0.00% | 27.92% | $7.52B |
| CHEChemed Corp | $520.15 | 26.2x | 8.2x | 0.54% | 27.11% | $6.8B |
About the company
- 1,480
- Carlsbad, United States