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SYRE
Spyre Therapeutics, Inc.
NASDAQ· Healthcare· Biotechnology· CUSIP 00773J202
$79.90-0.25%Price as of Oct 17, 12:22 UTC · updated once a day, after the close
At a glance
Spyre Therapeutics, Inc. (SYRE) is listed on NASDAQ and classified in Biotechnology, part of the Healthcare sector. It is headquartered in Waltham, United States and has 125 employees. The company is worth $7.47B. Revenue was $0 in fiscal 2025. It reported a net loss of $155.2M. The share price is 27.5% below its 52-week high of $110.18. 4 of the 38 superinvestors we track held it at the end of Q2 2026. The largest position belongs to Israel Englander (Millennium Management), at $17.46M. In that quarter, 2 of them opened or added to the position. Over the last 30 days, company insiders sold $6.28M of its stock on the open market and bought none. All of those sales were scheduled in advance under 10b5-1 plans.
Written from the data on this page: SEC filings (13F, Form 4, annual reports) and market prices.
Key metrics
- Market cap
- $7.47B
- P/E
- —
- Forward P/E
- —
- P/B
- 7.4x
- Dividend yield
- 0.00%
- Payout
- —
- EPS
- -$1.92
- ROE
- -22.98%
- Profit margin
- 0.00%
- Revenue growth
- —
- Beta
- 3.11
- 52-week high
- $110.18
- 52-week low
- $21.15
History
Year by year, from the annual reports; dividends from the payments themselves.
Bars are year-end balances; lines are what happened during the year.
Investors holding this
Major managers that reported this stock in their latest 13F.
Price over time
▼ -48.8% over 5Y.
today you would have $436.61▼ -56.3%
Dividends reinvested, splits accounted for. Past prices say what happened, not what will.
Indicators, year by year
The last 10 closed years, each at that year’s closing price and reported numbers.
| Indicator | Median | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Year-end price | $32.76 | $23.28 | $21.52 | $11.25 | $118.75 | $196.75 | $191.00 | $187.25 | $135.25 | $108.75 | |
| P/E | — | — | — | 1.6x | — | — | — | — | — | — | — |
| P/S | 15.0x |
Others in the same sector
Companies of similar size in Healthcare, for comparison. The columns are the same ones above, in the same order.
| Stock | Price | P/E | P/B | Dividend yield | ROE | Market cap |
|---|---|---|---|---|---|---|
| PACSPACS Group, Inc. | $47.50 | 27.3x | 6.8x | 0.00% | 27.92% | $7.52B |
| ALKSAlkermes plc. | $44.18 | 113.3x | 4.1x | 0.00% | 3.85% | $7.41B |
| IONSIonis Pharmaceuticals Inc | $43.91 | — | 16.5x | 0.00% | -105.50% | $7.3B |
| PRAXPraxis Precision Medicines, Inc. | $258.92 |
About the company
- 125
- Waltham, United States